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This study estimated the age of the most recent common ancestor (MRCA) of those CRF12_BF-like viruses between 19, and further suggests an extremely rapid spread of the CRF12_BF-like recombinant viruses, compatible with the demographic pattern of explosive population growth observed in this pediatric population at the start of the epidemic.
The objective of the present study was to reconstruct the evolutionary and demographic history of the CRF12_BF circulating in Argentina and Uruguay through the analysis of a large data set ( sequences to estimate the age and demographic history of the CRF38_BF epidemic spreading in Uruguay.
To date, however, very little is known about the evolutionary history and epidemic potential of the diverse BF1 recombinants that have expanded in the South American population.
Only one previous study was conducted on a small number (].
Sequences were considered to have a "CRF-like" profile if recombination sites exactly match those identified in CRF12_BF and CRF38_BF reference sequences.
2) Second, Bayesian and Maximum Likelihood (ML) phylogenetic trees for the final ].
The molecular epidemiology of HIV-1 in Uruguay is not so well characterized, but two previous studies suggested that BF1 recombinants circulating in this country are similar to those described in Argentina .
Based on monophyletic clustering and coincident recombination breakpoints, it was suggested that most BF1 recombinants circulating in Argentina and Uruguay derived from a common recombinant ancestor .
Brackets indicate the monophyletic clusters formed by each CRF.