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Consequently, the actual source of blood mi RNA biomarkers in gastric cancer has not been adequately evaluated and little is known about their distribution, particularly in the Western populations.To the best of our knowledge, this is the first study of comprehensive mi RNome profiling aimed at evaluating the origins of serum micro RNA biomarkers for GC.Gastric cancer (GC) is the third leading cause of cancer death and a major public health care problem worldwide, including in Western populations (Ferlay et al, 2015).There are only limited diagnostic methods for early detection and no effective screening programs outside some Asian countries (Veitch et al, 2015).Moreover, expression of mi R-331 and mi R-21 was significantly higher in the peripheral circulation compared to tumour-draining veins of the portal system.The results indicate that the majority of potential serum mi RNA biomarkers may originate from tissues other than the primary tumour.The study was planned as a prospective, open label clinical trial.
This article is available under the terms of the Creative Commons Attribution 3.0 License.Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI.This page is based on a Wikipedia article written by contributors (read/edit).Twenty treatment-naive patients with GC along with 20 cancer-free controls were recruited.
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mi RCURY LNA mi RNA microarrays were used for mi RNA expression profiling in primary tumours and adjacent healthy mucosa.
A group of 20 patients subject to upper gastrointestinal endoscopy for complaints related to non-malignant conditions, mostly GERD and cholelithiasis, was selected as controls.
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